The vacuolar K⁺/H⁺ exchangers and calmodulin-like CML18 constitute a pH-sensing module that regulates K⁺ status in Arabidopsis.

ABSTRACT: Shifts in cytosolic pH have been recognized as key signaling events and mounting evidence supports the interdependence between H⁺ and Ca²⁺ signaling in eukaryotic cells. Among the cellular pH-stats, K⁺/H⁺ exchange at various membranes is paramount in plant cells. Vacuolar K⁺/H⁺ exchangers of the NHX (Na⁺,K⁺/H⁺ exchanger) family control luminal pH and, together with K⁺ and H⁺ transporters at the plasma membrane, have been suggested to also regulate cytoplasmic pH. We show the regulation of vacuolar K⁺/H⁺ exchange by cytoplasmic pH and the calmodulin-like protein CML18 in Arabidopsis. The crystal structure and physicochemical properties of CML18 indic

SUBMITTER: Daniel-Mozo M 

PROVIDER: S-EPMC11559620 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature