EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica.

ABSTRACT: Macropinocytosis is an evolutionarily conserved endocytic process that plays a vital role in internalizing extracellular fluids and particles in cells. This non-selective endocytic pathway is crucial for various physiological functions such as nutrient uptake, sensing, signaling, antigen presentation, and cell migration. While macropinocytosis has been extensively studied in macrophages and cancer cells, the molecular mechanisms of macropinocytosis in pathogens are less understood. It has been known that Entamoeba histolytica, the causative agent of amebiasis, exploits macropinocytosis for survival and pathogenesis. Since macropinocytosis is initiated by actin polymerization, leading to the formation of membrane ruffles and the subsequent trapping of solutes in macropinosomes, actin cytosk

SUBMITTER: Shimoyama M 

PROVIDER: S-EPMC11560011 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature