Optical coherence tomography predictors of clinical outcomes after stent implantation: the ILUMIEN IV trial.

ABSTRACT:

Background and aims

Observational registries have suggested that optical coherence tomography (OCT) imaging-derived parameters may predict adverse events after drug-eluting stent (DES) implantation. The present analysis sought to determine the OCT predictors of clinical outcomes from the large-scale ILUMIEN IV trial.

Methods

ILUMIEN IV was a prospective, single-blind trial of 2487 patients with diabetes or high-risk lesions randomized to OCT-guided versus angiography-guided DES implantation. All patients underwent final OCT imaging (blinded in the angiography-guided arm). From more than 20 candidates, the independent OCT predictors of 2-year target lesion failure (TLF; the primary endpoint), cardiac death or target-vessel myocardial infarction (TV-MI), ischaemia-driven targe

SUBMITTER: Landmesser U 

PROVIDER: S-EPMC11560276 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature