Plasma proteome and incident myocardial infarction: sex-specific differences.

ABSTRACT:

Background and aims

Few population-based cohort studies, including both men and women, have explored circulating proteins associated with incident myocardial infarction (MI). This study investigated the relationships between circulating cardiometabolic-related proteins and MI risk using cohort-based and Mendelian randomization (MR) analyses and explored potential sex-specific differences.

Methods

The discovery cohort included 11 751 Swedish adults (55-93 years). Data on 259 proteins assessed with Olink proximity extension assays, biochemical, and questionnaire-based information were used. Participants were followed up for incident MI and death over 8 years through linkage to Swedish registers. Replication analyses were conducted on the UK Biobank sample (n = 51 613). In MR a

SUBMITTER: Titova OE 

PROVIDER: S-EPMC11560279 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature