Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis.

ABSTRACT:

Background and aims

Somatic mutations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice and a higher risk of atherosclerotic disease in humans. Mechanistically, these observations have been linked to exacerbated vascular inflammation. This study aimed to evaluate whether colchicine, a widely available and inexpensive anti-inflammatory drug, prevents the accelerated atherosclerosis associated with TET2-mutant CH.

Methods

In mice, TET2-mutant CH was modelled using bone marrow transplantations in atherosclerosis-prone Ldlr-/- mice. Haematopoietic chimeras carrying initially 10% Tet2-/- haematopoietic cells were fed a high-cholesterol diet and treated with colchicine or placebo. In humans, whole-exome seq

SUBMITTER: Zuriaga MA 

PROVIDER: S-EPMC11560281 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature