Candida albicans infection model in Drosophila melanogaster suggests a strain-specific virulent factor boosting a stormy innate immune response.

ABSTRACT:

Intorduction

Pathogens drive the evolution of host defence strategies, with both innate and adaptive immune systems playing key roles. Priming enhances the innate immune system's readiness by functionally reprogramming immune cells after initial exposure to stimuli, like β-glucans. In this sense, Drosophila melanogaster is a valuable model to evaluate the role of innate immunity to control infections.

Objectives

In this study we aimed to set light on the immune priming effect of oral treatment with heat-killed M. manresensis and two different heat-killed C. albicans isolates upon systemic infection by C. albicans in the D. melanogaster model.

Methods

A clinical and a control ATCC 90028 Candida albicans strain were used. Flies

SUBMITTER: Cortacans M 

PROVIDER: S-EPMC11560421 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature