<i>In silico</i> identification and verification of Tanshinone IIA-related prognostic genes in hepatocellular carcinoma.

ABSTRACT:

Background

Currently, adequate treatment and prognostic prediction means for Hepatocellular Carcinoma (HCC) haven't entered into medical vision. Tanshinone IIA (TanIIA) is a natural product, which can be utilized as a potential treatment of HCC due to its high anti-tumor activity. However, the effect on HCC prognosis, as well as the potential targets and molecular mechanism of TanIIA still remain ambiguous. Herein, we investigated them via network pharmacology, explored TanIIA-related prognostic genes by machine learning methods, and verified using molecular docking and cell experiments.

Methods

Potential TanIIA-targeted genes and HCC-related genes were obtained from the corresponding database. The Protein-Protein Interaction (PPI) network and enrichment analyses of the inte

SUBMITTER: Qian L 

PROVIDER: S-EPMC11560438 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature