Possible involvement of Toll-like receptor 8-positive monocytes/macrophages in the pathogenesis of Sjogren's disease.

ABSTRACT:

Background

Sjögren's disease (SjD) is an autoimmune disease marked by lymphocytic infiltration of salivary and lacrimal glands, leading to glandular dysfunction, where CD4-positive helper T (Th) cells and their cytokines are crucial in the pathogenesis. Recent studies have demonstrated that Toll-like receptors (TLRs), particularly those recognizing immune complexes containing DNA and RNA, contribute to Th cell activation in various autoimmune diseases. This study explores the expression and function of these TLRs in SjD.

Methods

DNA microarray analysis of salivary gland tissue from six SjD patients and real-time PCR (n = 32) was used to identify overexpressed TLRs. Single-cell RNA sequencing (scRNA-seq) was performed using tissue lesions and integrated with published scRNA-s

SUBMITTER: Yan L 

PROVIDER: S-EPMC11560440 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature