Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families.

ABSTRACT:

Objective

IBD is characterised by dysbiosis, but it remains unclear to what extent dysbiosis develops in unaffected at-risk individuals. To address this, we investigated age-related patterns of faecal and serum markers of dysbiosis in high-risk multiplex IBD families (two or more affected first-degree relatives).

Design

Faecal and serum samples were collected from multiplex IBD and control families (95 IBD, 292 unaffected, 51 controls). Findings were validated in independent cohorts of 616 and 1173 subjects including patients with IBD, infants born to mothers with IBD and controls. 16S rRNA gene sequencing and global untargeted metabolomics profiling of faeces and serum were performed.

Results

Microbial and metabolomic parameters of dysbiosis progressively decreased f

SUBMITTER: Jacobs JP 

PROVIDER: S-EPMC11560537 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature