Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes. We aimed to perform a comprehensive meta-analysis of all randomized, sham-controlled trials investigating RDN with first- and second-generation devices in hypertension.

Methods

We searched MEDLINE and the Cochrane Library for eligible trials. Outcomes included both efficacy (24-hour and office systolic [SBP] and diastolic blood pressure [DBP]) and safety (all-cause death, vascular complication, renal artery stenosis >70%, hypertensive crisis) of RDN. We performed a study-level, pairwise, random-effects meta-analysis of the summary data.

Results

Ten trials comprising 2478 patients with hypertension while being either off or

SUBMITTER: Vukadinovic D 

PROVIDER: S-EPMC11560572 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature