Cardiovascular disease and stroke following cancer and cancer treatment in older adults.

ABSTRACT:

Background

Cancer survivors can be at risk of cardiovascular disease (CVD) because of either their malignancy or its treatment. Although studies linking cancer and CVD exist, few examine risk in older adults, the impact of cancer treatment, or the effect of aspirin on reducing risk in this cohort.

Methods

The authors conducted a secondary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial to investigate the impact of cancer and cancer treatment on a composite CVD end point comprising hospitalization for heart failure (HHF), myocardial infarction (MI), and stroke.

Results

Of 15,454 Australian and US ASPREE participants, 1392 had an incident cancer diagnosis. Rates of CVD were greater in the cancer risk-set compared to the cancer-free risk-set (20.

SUBMITTER: Muhandiramge J 

PROVIDER: S-EPMC11560579 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature