Non-IgE-mediated drug-induced hypersensitivity reactions in pediatrics.

ABSTRACT:

Purpose of review

Despite their prevalence and potential severity, non-IgE-mediated drug-induced hypersensitivity reactions (DHRs) are under-researched and poorly defined, particularly in children. Presentations range from mild cutaneous reactions to severe systemic diseases, with pathophysiological mechanisms and reliable diagnostic markers not well established. The lack of validated tests often leads to permanent drug restrictions, reliance on second-line drugs, and increased costs. Focusing on recent advancements and areas needing further research, this review aims to enhance children's recognition, diagnosis, and management of non-IgE-mediated DHRs.

Recent findings

Recent studies have enhanced the understanding of immediate and delayed non-IgE-mediated drug reactions. Ke

SUBMITTER: Chow TG 

PROVIDER: S-EPMC11560661 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature