Mendelian randomization analysis of causal and druggable circulating inflammatory proteins in schizophrenia.

ABSTRACT:

Background

Schizophrenia (SZ) is a severe mental disorder with complex origins. Observational studies suggested that inflammatory factors may play a role in the pathophysiology of SZ and we aim to investigate the potential genetic connection between them by examining the causal impact of circulating inflammatory proteins on SZ.

Methods

We utilized Mendelian randomization (MR) analysis to assess the causal relationship between circulating inflammatory proteins and SZ and the GWAS summary datasets were sourced from public databases. The SZ dataset comprised 74,776 cases and 101,023 controls, while the summary results for 91 plasma proteins in 14,824 participants were obtained through the Olink Target platform. Moreover, to identify and evaluate potential drug targets, we searc

SUBMITTER: Cao H 

PROVIDER: S-EPMC11560794 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature