Comprehensive analysis of the oncogenic potential of eukaryotic initiation factor 3M via SAAL1 interaction in lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) carries a poor prognosis at advanced stages underscoring the need to elucidate the underlying molecular mechanisms driving its pathogenesis. This study aimed to investigate the roles of eukaryotic translation initiation factor 3 subunit M (EIF3M) and its associated effector, serum amyloid A-like 1 (SAAL1), in LUAD development and progression. Bioinformatic analyses such as TNMplot, The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and other public databases were used to evaluate EIF3M and SAAL1 expression levels, methylation status, clinical associations, and potential transcriptional regulators across LUAD datasets. Patient samples were analyzed for EIF3M/SAAL1 expression by qRT-PCR, immunohistochemistry, an

SUBMITTER: Chiang HH 

PROVIDER: S-EPMC11560815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature