Calcium-permeable AMPA receptors govern PV neuron feature selectivity.

ABSTRACT: The brain helps us survive by forming internal representations of the external world^1,2. Excitatory cortical neurons are often precisely tuned to specific external stimuli^3,4. However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective⁵. PV interneurons differ from excitatory neurons in their neurotransmitter receptor subtypes, including AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs)^6,7. Excitatory neurons express calcium-impermeable AMPARs that contain the GluA2 subunit (encoded by GRIA2), whereas PV interneurons express receptors that lack the GluA2 subunit and are calcium-permeable (CP-AMPARs). Here we demonstrate a causal relationship between CP-AMPAR expression an

SUBMITTER: Hong I 

PROVIDER: S-EPMC11560848 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature