The microbiome biomarkers of pregnant women's vaginal area predict preterm prelabor rupture in Western China.

ABSTRACT:

Introduction

Intraamniotic infection is crucial in preterm prelabor rupture of membranes(PPROM), a clinical condition resulting from the invasion of vaginal opportunistic microbes into the amniotic cavity. Although previous studies have suggested potential associations between infection and PPROM, the role of vaginalopportunistic bacteria in PPROM has received limited attention.

Methods

This study aimed to confirm the vaginal bacterial etiology of PPROM. We investigated vaginal microbiotas using automatic analysis of vaginal discharge, microbiological tests, and 16s rRNA genehigh-throughput sequencing.

Results

The research findings revealed that the proportion of parabasal epitheliocytes, leukocytes, toxic leukocytes, and bacteria with diameters smaller than 1.5 um wa

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11560878 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature