Pathogen spectrum and microbiome in lower respiratory tract of patients with different pulmonary diseases based on metagenomic next-generation sequencing.

ABSTRACT:

Introduction

The homeostasis of the microbiome in lower respiratory tract is crucial in sustaining normal physiological functions of the lung. Different pulmonary diseases display varying degrees of microbiome imbalance; however, the specific variability and clinical significance of their microbiomes remain largely unexplored.

Methods

In this study, we delineated the pathogen spectrum and commensal microorganisms in the lower respiratory tract of various pulmonary diseases using metagenomic sequencing. We analyzed the disparities and commonalities of the microbial features and examined their correlation with disease characteristics.

Results

We observed distinct pathogen profiles and a diversity in lower airway microbiome in patients diagnosed with cancer, interstitial

SUBMITTER: Hong R 

PROVIDER: S-EPMC11560916 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature