The role of gut microbial β-glucuronidases in carcinogenesis and cancer treatment: a scoping review.

ABSTRACT:

Introduction

The human gut microbiota influence critical functions including the metabolism of nutrients, xenobiotics, and drugs. Gut microbial β-glucuronidases (GUS) enzymes facilitate the removal of glucuronic acid from various compounds, potentially affecting anti-cancer drug efficacy and reactivating carcinogens. This review aims to comprehensively analyze and summarize studies on the role of gut microbial GUS in cancer and its interaction with anti-cancer treatments. Its goal is to collate and present insights that are directly relevant to patient care and treatment strategies in oncology.

Methods

This scoping review followed PRISMA-ScR guidelines and focused on primary research exploring the role of GUS within the gut microbiota related to cancer etiology and anti-canc

SUBMITTER: Hillege LE 

PROVIDER: S-EPMC11561038 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature