Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide.

ABSTRACT: Voltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases. This study explores Tityus bahiensis scorpion venom for neuroactive peptides. We identified the αKtx12 peptide as a potent neuroprotective agent. In SH-SY5Y cells, αKtx12 significantly enhances viability, validating its pharmacological potential. And in the animal model, we elucidate central nervous system (CNS) mechanism of αKtx12 through neuroproteomic analyses highlighting αKtx12 as a valuable tool for characterizing neuroplasticity and neurotropism, revealing its ability to elicit more physiological responses. The peptide's potential to promote cell proliferation and neuroprotection suggests a role in functi

SUBMITTER: Beraldo-Neto E 

PROVIDER: S-EPMC11561340 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature