Hearing Function Moderates Age-Related Differences in Brain Morphometry in the HCP Aging Cohort.

ABSTRACT: There are well-established relationships between aging and neurodegenerative changes, and between aging and hearing loss. The goal of this study was to determine how structural brain aging is influenced by hearing loss. Human Connectome Project Aging data were analyzed, including T1-weighted Magnetic Resonance Imaging (MRI) and Words in noise (WIN) thresholds (n = 623). Freesurfer extracted gray and white matter volume, and cortical thickness, area, and curvature. Linear regression models targeted (1) interactions between age and WIN threshold and (2) correlations with WIN threshold adjusted for age, both corrected for false discovery rate (p_FDR < 0.05). WIN threshold moderated age-related increase in volume in bilateral inferior lateral ventricles, with a higher threshold assoc

SUBMITTER: Kirschen RM 

PROVIDER: S-EPMC11561423 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature