Association of Lipoprotein(a) With Severe Degenerative Aortic Valve Stenosis.

ABSTRACT:

Background

Lipoprotein(a) (Lp[a]) is associated with the development of aortic valve calcification.

Objectives

The aim of this study was to evaluate the association between the serum level of Lp(a) and the development of severe degenerative aortic stenosis (AS) and subsequent aortic valve replacement (AVR).

Methods

A total of 44,742 patients with Lp(a) measurements and echocardiography at baseline evaluation between 2000 and 2020 were included from a single tertiary heart center. The primary outcome was the development of severe degenerative AS, defined as a transaortic maximal velocity of ≥4.0 m/s.

Results

During a median follow-up period of 6.8 years (Q1-Q3: 2.3-12.4 years), severe degenerative AS was diagnosed in 472 patients (1.1%), and subsequent AVR was p

SUBMITTER: Kim AR 

PROVIDER: S-EPMC11561479 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature