Prognostic Analysis of Lactic Acid Metabolism Genes in Oral Squamous Cell Carcinoma.

ABSTRACT:

Objectives

Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in the oral and maxillofacial region. Lactic acid accumulation in the tumour microenvironment (TME) has gained attention for its dual role as an energy source for cancer cells and an activator of signalling pathways crucial to tumour progression. This study aims to reveal the impact of lactate-related genes (LRGs) on the prognosis, TME, and immune characteristics of OSCC, with the ultimate goal of developing a novel prognostic model.

Methods

Unsupervised clustering analysis of LRGs in OSCC patients from The Cancer Genome Atlas database was conducted to evaluate and compare TME, immune features, and clinical characteristics across various lactate subtypes. A refined prognostic model was develop

SUBMITTER: Shen S 

PROVIDER: S-EPMC11561504 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature