Unique tau- and synuclein-dependent metabolic reprogramming in neurons distinct from normal aging.

ABSTRACT: Neuronal cells are highly specialized cells and have a specific metabolic profile to support their function. It has been demonstrated that the metabolic profiles of different cells/tissues undergo significant reprogramming with advancing age, which has often been considered a contributing factor towards aging-related diseases including Alzheimer's (AD) and Parkinson's (PD) diseases. However, it is unclear if the metabolic changes associated with normal aging predispose neurons to disease conditions or a distinct set of metabolic alterations happen in neurons in AD or PD which might contribute to disease pathologies. To decipher the changes in neuronal metabolism with age, in AD, or in PD, we performed high-throughput steady-state metabolite profiling on heads in wildtype Drosophila and in

SUBMITTER: Yadav S 

PROVIDER: S-EPMC11561663 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature