Wide-ranging genetic variation in sensitivity to rapamycin in Drosophila melanogaster.

ABSTRACT: The progress made in aging research using laboratory organisms is undeniable. Yet, with few exceptions, these studies are conducted in a limited number of isogenic strains. The path from laboratory discoveries to treatment in human populations is complicated by the reality of genetic variation in nature. To model the effect of genetic variation on the action of the drug rapamycin, here we use the growth of Drosophila melanogaster larvae. We screened 140 lines from the Drosophila Genetic References Panel for the extent of developmental delay and found wide-ranging variation in their response, from lines whose development time is nearly doubled by rapamycin, to those that appear to be completely resistant. Sensitivity did not associate with any single genetic marker, nor with any gene. Howev

SUBMITTER: Harrison BR 

PROVIDER: S-EPMC11561674 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature