Joint modelling of survival and backwards recurrence outcomes: an analysis of factors associated with fertility treatment in the U.S.

ABSTRACT: The motivation for this paper is to determine factors associated with time-to-fertility treatment (TTFT) among women currently attempting pregnancy in a cross-sectional sample. Challenges arise due to dependence between time-to-pregnancy (TTP) and TTFT. We propose appending a marginal accelerated failure time model to identify risk factors of TTFT with a model for TTP where fertility treatment is included as a time-varying treatment to account for their dependence. The latter requires extending backwards recurrence survival methods to incorporate time-varying covariates with time-varying coefficients. Since backwards recurrence survival methods are a function of mean survival, computational difficulties arise in formulating mean survival when fertility treatment is unobserved, i.e. when TT

SUBMITTER: Guo S 

PROVIDER: S-EPMC11561729 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature