Sweet pepper extract reduces fat storage in Caenorhabditis elegans by SREBP-SCD axis based on multiomics analysis.

ABSTRACT: Sweet pepper, a globally commercialized horticultural crop, has been demonstrated to impede fat accumulation, but its mechanism remains incompletely understood. This study was designed to explore the potential mechanism of sweet pepper in reducing fat accumulation in Caenorhabditis elegans through RNA-seq and metabolome analysis. A total of 22 metabolites were identified from sweet pepper by UHPLC-ESI-TOF-MS analysis. In vivo, sweet pepper significantly inhibited α-glucosidase activity and reduced the levels of glucose, triglycerides (TG), total cholesterol (TC), and the area stained with oil red O. Additionally, it increased body length and the number of head swings in C. elegans compared to the control group. The KEGG enrichment analysis revealed significant enrichment of t

SUBMITTER: Wang J 

PROVIDER: S-EPMC11561784 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature