Versatile tissue-injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics.

ABSTRACT: Hydrogels are extensively employed in healthcare due to their adaptable structures, high water content, and biocompatibility, with FDA-approved applications ranging from spinal cord regeneration to local therapeutic delivery. However, clinical hydrogels encounter challenges related to inconsistent therapeutic exposure, unmodifiable release windows, and difficulties in subsurface polymer insertion. Addressing these issues, we engineered injectable, biocompatible hydrogels as a local therapeutic depot, utilizing poly(ethylene glycol) (PEG)-based hydrogels functionalized with bioorthogonal SPAAC handles for network polymerization and functionalization. Our hydrogel solutions polymerize in situ in a temperature-sensitive manner, persist in tissue, and facilitate the delivery of bioactive thera

SUBMITTER: Nealy ES 

PROVIDER: S-EPMC11561820 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature