Hepatoprotective effects of Juglans regia on carbon tetrachloride-induced hepatotoxicity: In silico/in vivo approach.

ABSTRACT: Juglans regia L. is a well-known therapeutic plant in Nepal, employed in traditional medicine for treating liver ailments. This study aimed to evaluate the in vivo and in silico liver-protective effects of J. regia extract using a carbon tetrachloride (CCl₄)-induced hepatic damage rat model. Healthy male rats were randomly divided into six groups: normal control (distilled water 10 mL/kg), toxic control (distilled water 10 mL/kg), standard test (silymarin 100 mg/kg), and three groups receiving oral J. regia extracts (125, 250, and 500 mg/kg/day) for seven days. On the eighth day, carbon tetrachloride (CCl₄) was administered intraperitoneally (i.p.) (1.5 mL/kg in 1:1 olive oil ratio for all groups, except the normal control). Rats were sacrificed o

SUBMITTER: Pandey B 

PROVIDER: S-EPMC11561823 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature