Garlic peel extract as an antioxidant inhibits triple-negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase-2 expression.

ABSTRACT: Garlic peels are frequently disposed of as agro-waste; their bioactivity and physiological activity for health benefits and disease protection are neglected. This study aims to examine the potential inhibitory effects of garlic peel extract as an antioxidant on 4 T1 triple-negative breast cancer (TNBC) tumors in mice. The bioactive constituents of garlic peel were identified through HPLC-MS/MS analysis, while the antioxidant properties of garlic peel extract were assessed using peroxyl radical scavenging capacity (PSC) and cellular antioxidant activity (CAA) assays. Subsequently, the inhibitory effects of garlic peel extract on 4T1 tumor growth were evaluated using a 4T1 model. The results showed that 433 polyphenol compounds were found in garlic peel extract; among them, flavonoids and ph

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11561839 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature