Feasibility of using a standardized <i>Caenorhabditis elegans</i> toxicity test to assess nanomaterial toxicity.

ABSTRACT: Increasing production and use of engineered nanomaterials (ENMs) has generated widespread interest in measuring their environmental and human health effects. However, the lack of standardized methods for these measurements has often led to contradictory results. Our goal in this study was to examine the feasibility of using a standardized Caenorhabditis elegans growth and reproduction based toxicity test designed for use with dissolved chemicals to assess ENM toxicity. Sensitivity testing of seven key experimental factors identified by cause-and-effect analysis revealed that bacterial feed density and plate shaking had significant effects on growth inhibition by a reference toxicant, benzylcetyldimethylammonium chloride (BAC-C16). Bacterial density was inversely proportional to expe

SUBMITTER: Hanna SK 

PROVIDER: S-EPMC11561884 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature