COVID-19-related morbidity and mortality in people with multiple long-term conditions: a systematic review and meta-analysis of over 4 million people.

ABSTRACT:

Objectives

To describe the direct impact of coronavirus disease 2019 (COVID-19) infection on morbidity and mortality in people with multiple long-term conditions (MLTCs).

Design

A systematic review and meta-analysis including observational studies.

Setting

Studies conducted between 1 January 2020 and 4 May 2023 across 51 countries were identified from five databases.

Participants

A total of 4,084,469 patients with confirmed COVID-19 infection.

Main outcome measures

Pooled risk ratios (RRs) for mortality, hospitalisation, severe disease, intensive care unit (ICU) admission and mechanical ventilation were estimated with random effect meta-analysis models.

Results

A total of 38,356 studies were identified and 111 included. In most (74%) of the studie

SUBMITTER: Salisu-Olatunji SO 

PROVIDER: S-EPMC11561988 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature