Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis.

ABSTRACT:

Background

Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes.

Objectives

We sought to define morphometric characteristics of childhood EED and determine whether morphology features were associated with disease pathophysiology.

Methods

Morphometric measurements and histology were assessed on duodenal biopsy slides for this cross-sectional study from children with EED in Bangladesh, Pakistan, and Zambia (n = 69), and those with no pathologic abnormality (NPA; n = 8) or celiac disease (n = 18) in North America. Immunohistochemistry was also conduct

SUBMITTER: Ehsan L 

PROVIDER: S-EPMC11562031 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature