Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers.

ABSTRACT:

Background

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeability, increased microbial translocation, and nutrient loss.

Objectives

We sought to identify dysregulated genes and pathways that might underlie pediatric EED.

Methods

RNA-sequencing libraries were generated from endoscopically obtained duodenal tissue from undernourished children with EED from 3 prospective cohorts of children with EED. The EED transcriptome was defined in comparison to North American children without EED. Weighted gene coexpression network ana

SUBMITTER: Marie C 

PROVIDER: S-EPMC11562032 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature