DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data.

ABSTRACT:

Background

This study aimed to identify DNA methylation biomarkers associated with myopia using summary-data-based Mendelian randomization (SMR).

Methods

A systematic search of the PubMed, Web of Science, Cochrane Library, and Embase databases was conducted up to March 27, 2024. SMR analyses were performed to integrate genome-wide association study (GWAS) with methylation quantitative trait loci (mQTL) and expression quantitative trait loci (eQTL) studies. The heterogeneity in the dependent instrument (HEIDI) test was utilized to distinguish pleiotropic associations from linkage disequilibrium.

Results

The systematic review identified 26 DNA methylation biomarkers in five studies, with no overlap observed among those identified by different studies. After integrating

SUBMITTER: Dong XX 

PROVIDER: S-EPMC11562087 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature