Metabolic-driven analytics of traumatic brain injury and neuroprotection by ethyl pyruvate.

ABSTRACT:

Background

Research on traumatic brain injury (TBI) highlights the significance of counteracting its metabolic impact via exogenous fuels to support metabolism and diminish cellular damage. While ethyl pyruvate (EP) treatment shows promise in normalizing cellular metabolism and providing neuroprotection, there is a gap in understanding the precise metabolic pathways involved. Metabolomic analysis of the acute post-injury metabolic effects, with and without EP treatment, aims to deepen our knowledge by identifying and comparing the metabolite profiles, thereby illuminating the injury's effects and EP's therapeutic potential.

Methods

In the current study, an untargeted metabolomics approach was used to reveal brain metabolism changes in rats 24 h after a controlled cortical im

SUBMITTER: Golovachev N 

PROVIDER: S-EPMC11562096 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature