T1-weighted MRI texture analysis in amyotrophic lateral sclerosis patients stratified by the D50 progression model.

ABSTRACT: Amyotrophic lateral sclerosis, a progressive neurodegenerative disease, presents challenges in predicting individual disease trajectories due to its heterogeneous nature. This study explores the application of texture analysis on T1-weighted MRI in patients with amyotrophic lateral sclerosis, stratified by the D50 disease progression model. The D50 model, which offers a more nuanced representation of disease progression than traditional linear metrics, calculates the sigmoidal curve of functional decline and provides independent quantifications of disease aggressiveness and accumulation. In this research, a representative cohort of 116 patients with amyotrophic lateral sclerosis was studied using the D50 model and texture analysis on MRI images. Texture analysis, a technique used for quant

SUBMITTER: Parnianpour P 

PROVIDER: S-EPMC11562117 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature