Euphorbium compositum SN improves the innate defenses of the airway mucosal barrier network during rhinovirus infection.

ABSTRACT:

Background

Rhinoviruses (RV) are the major cause of common colds in healthy individuals and are associated with acute exacerbations in patients with chronic lung diseases. Yet, no vaccines or effective treatment against RV are available. This study investigated the effect of Euphorbium compositum SN (ECSN6), a multicomponent, multitarget medication made from natural ingredients, on the mucosal barrier network during RV infection.

Methods

Mucociliary-differentiated airway epithelial cell cultures were infected with RV or sham, and treated with 20% ECSN6 or placebo twice daily. Barrier integrity was assessed by measuring transepithelial resistance (TER), permeability to inulin, and expression and localization of intercellular junctions proteins (IJ). Ciliary beat frequency (CB

SUBMITTER: Rajput C 

PROVIDER: S-EPMC11562495 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature