Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection.

ABSTRACT: Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function during ageing. However, the impact of ageing on macrophage function in response to an IAV infection remains unclear and offers potential insight for underlying mechanisms. In this study, we investigated the immune response of young and aged human monocyte-derived macrophages to two different H1N1 IAV strains. Interestingly, macrophages of aged individuals showed a lower interferon response to IAV infection, resulting in increased viral load. Transcriptomic data revealed a reduced expression of stimulator of interferon genes (STING) in aged macrophages albeit

SUBMITTER: Lauf T 

PROVIDER: S-EPMC11562583 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature