Identification and characterization of novel ferroptosis-related genes in acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is a leading cause of death and morbidity worldwide. Ferroptosis, a form of regulated cell death, plays a critical role in modulating immune functions during AMI. This study aimed to identify ferroptosis-related hub genes that could serve as potential therapeutic targets in the progression of AMI.

Methods

Bioinformatics was used to identify overlapping genes associated with ferroptosis and the infiltration of 22 immune cells by Cell-type Identification by Estimating Relative Subsets of RNA Transcript (CIBERSORT) analysis. The expression of ferroptosis-related genes in AMI was validated across independent datasets, clinical samples, and in vitro cellular experiments. The predictive value for heart failure was evaluated in the first

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11562590 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature