Caffeine Inhibits Both Basal and Insulin-Activated Urate Transport.

ABSTRACT:

Objective

Caffeine, an adenosine receptor antagonist, is a potent central nervous system stimulant that also impairs insulin signaling. Recent studies have suggested that coffee consumption lowers serum urate (SU) and protects against gout by unknown mechanisms. We hypothesized that caffeine lowers SU by affecting activity of urate transporters.

Methods

We examined the effect of caffeine and adenosine on basal and insulin stimulation of net ¹⁴C-urate uptake in the human renal proximal tubule cell line PTC-05 and on individual urate transporters expressed in Xenopus laevis oocytes.

Results

We found that caffeine and adenosine efficiently inhibited both basal and insulin stimulation of net ¹⁴C-urate uptake mediated by endogenous urate transporters

SUBMITTER: Mandal AK 

PROVIDER: S-EPMC11562663 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature