Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Benzene is a recognized carcinogen; however, its association with breast cancer is not well established. Hence, a meta-analysis of cohort and case-control studies was performed to determine the association between occupational benzene exposure and the risk of breast cancer.

Methods

A systematic literature review identified 7573 publications from which 23 cohort and case-control studies were retained and evaluated using meta-analyses (fixed effects model). PRISMA guidelines were followed. Our protocol was registered in the PROSPERO database (Registration No. CRD42022379720). Study quality was assessed using a modified Newcastle-Ottawa scale (NOS).

Results

The summary relative risk (RR) for ever-benzene exposure was 1.08 (95% CI=1.03-1.14, I2=38.6%, n=23 ri

SUBMITTER: Seyyedsalehi MS 

PROVIDER: S-EPMC11562665 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature