Longitudinal changes of serum metabolomic profile after laparoscopic sleeve gastrectomy in obesity.

ABSTRACT:

Background

Bariatric surgery induces significant weight loss, increases insulin sensitivity, and improves dyslipidemia. As one of the most widely performed bariatric surgeries, laparoscopic sleeve gastrectomy (LSG) is thought to improve the metabolic profile along with weight loss. The objective of this study was to evaluate longitudinal changes in the serum metabolite levels after LSG and elucidate the underlying mechanisms of metabolic improvement.

Methods

Clinical metabolic parameters and serum samples were collected preoperatively and at 1, 3, and 6 months postoperatively from nine patients with obesity undergoing LSG. Serum metabolites were measured using a non-targeted metabolic liquid chromatography-mass spectrometry method.

Results

During the 1, 3, and 6 month

SUBMITTER: Li S 

PROVIDER: S-EPMC11562687 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature