PVACview: an interactive visualization tool for efficient neoantigen prioritization and selection.

ABSTRACT:

Background

Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these therapies have been initiated globally. Accurate identification and prioritization of neoantigens is crucial for designing these trials, predicting treatment response, and understanding mechanisms of resistance. With the advent of massively parallel DNA and RNA sequencing technologies, it is now possible to computationally predict neoantigens based on patient-specific variant information. However, numerous factors must be considered when prioritizing neoantigens for use in personalized therapies. Complexities such as alternative transcript annotat

SUBMITTER: Xia H 

PROVIDER: S-EPMC11562694 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature