Modeling ventilation of patients with interstitial lung disease at rest and exercise: a bench study.

ABSTRACT:

Background

The ventilatory physiopathology of patients with interstitial lung disease (ILD) remains poorly understood. We aimed to personalize a mechanical simulator to model healthy and ILD profiles ventilation, and to evaluate the effect of spontaneous breathing on respiratory mechanics at rest and during exercise.

Methods

In a 2-compartment lung simulator (ASL 5000^®), we modeled 1 healthy and 3 ILD profiles, at rest and during exercise, based on physiological data from literature and patients. Measurements were: tidal volume, end-expiratory lung volume, driving pressure, transpulmonary driving pressure, dynamic alveolar strain, mechanical power, and time lag of inspiratory flow between compartments 1 and 2.

Results

Healthy and ILD models were validated:

SUBMITTER: Artaud-Macari E 

PROVIDER: S-EPMC11562701 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature