Noninvasive targeted modulation of pain circuits with focused ultrasonic waves.

ABSTRACT:

Abstract

Direct interventions into deep brain circuits constitute promising treatment modalities for chronic pain. Cingulotomy and deep brain stimulation targeting the anterior cingulate cortex have shown notable improvements in the unpleasantness of pain, but these interventions require brain surgeries. In this study, we have developed an approach that can modulate this deep brain affective hub entirely noninvasively, using low-intensity transcranial-focused ultrasound. Twenty patients with chronic pain received two 40-minute active or sham stimulation protocols and were monitored for one week in a randomized crossover trial. Sixty percent of subjects experienced a clinically meaningful reduction of pain on day 1 and on day 7 following the active stimulation, while sham stimulatio

SUBMITTER: Riis TS 

PROVIDER: S-EPMC11562753 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature