Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates.

ABSTRACT:

Background

Current effective breast cancer treatment options have severe side effects, highlighting a need for new therapies. Drug repurposing can accelerate improvements to care, as FDA-approved drugs have known safety and pharmacological profiles. Some drugs for other conditions, such as metformin, an antidiabetic, have been tested in clinical trials for repurposing for breast cancer. Here, we exploit the genetics of breast cancer and linked predisposing diseases to propose novel drug repurposing opportunities. We hypothesize that if a predisposing disease contributes to breast cancer pathology, identifying the pleiotropic genes related to the risk of cancer could prioritize drugs, among all drugs treating a predisposing disease. We aim to develop a method to not only prioritize

SUBMITTER: Lalagkas PN 

PROVIDER: S-EPMC11562851 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature