Metapopulation model of phage therapy of an acute <i>Pseudomonas aeruginosa</i> lung infection.

ABSTRACT: Infections caused by multidrug resistant (MDR) pathogenic bacteria are a global health threat. Bacteriophages ("phage") are increasingly used as alternative or last-resort therapeutics to treat patients infected by MDR bacteria. However, the therapeutic outcomes of phage therapy may be limited by the emergence of phage resistance during treatment and/or by physical constraints that impede phage-bacteria interactions in vivo. In this work, we evaluate the role of lung spatial structure on the efficacy of phage therapy for Pseudomonas aeruginosa infections. To do so, we developed a spatially structured metapopulation network model based on the geometry of the bronchial tree, including host innate immune responses and the emergence of phage-resistant bacterial mutants. We model

SUBMITTER: Rodriguez-Gonzalez RA 

PROVIDER: S-EPMC11562898 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature