Brain Age Gap as a Predictor of Early Treatment Response and Functional Outcomes in First-Episode Schizophrenia: A Longitudinal Study: L'ecart d'age cerebral comme predicteur de la reponse en debut de traitement et des resultats fonctionnels dans un premier episode de schizophrenie : une etude longitudinale.

ABSTRACT:

Objectives

Accelerated brain aging, i.e., the age-related structural changes in the brain appearing earlier than expected from one's chronological age, is a feature that is now well established in schizophrenia. Often interpreted as a feature of a progressive pathophysiological process that typifies schizophrenia, its prognostic relevance is still unclear. We investigate its role in response to antipsychotic treatment in first-episode schizophrenia.

Methods

We recruited 49 drug-naive patients with schizophrenia who were then treated with risperidone at a standard dose range of 2-6 mg/day. We followed them up for 3 months to categorize their response status. We acquired T1-weighted anatomical images and used the XGboost method to evaluate individual brain age. The brain age g

SUBMITTER: Fan L 

PROVIDER: S-EPMC11562934 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature