Investigation of multiple sclerosis-related pathways through the integration of genomic and proteomic data.

ABSTRACT:

Background

Multiple sclerosis (MS) has a complex pathophysiology, variable clinical presentation, and unpredictable prognosis; understanding the underlying mechanisms requires combinatorial approaches that warrant the integration of diverse molecular omics data.

Methods

Here, we combined genomic and proteomic data of the same individuals among a Turkish MS patient group to search for biologically important networks. We previously identified differentially-expressed proteins by cerebrospinal fluid proteome analysis of 179 MS patients and 42 non-MS controls. Among this study group, 11 unrelated MS patients and 60 independent, healthy controls were subjected to whole-genome SNP genotyping, and genome-wide associations were assessed. Pathway enrichment analyses of MS-associated

SUBMITTER: Everest E 

PROVIDER: S-EPMC11563213 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature