Mechanistic Studies and Identification of Catalyst Deactivation Pathways for Pyridine(diimine) Iron Catalyzed C(sp²)-H Borylation.

ABSTRACT: The synthesis and application of aryl-substituted pyridine(diimine) iron complexes (^RPDI)FeCH₃ to the catalytic borylation of heteroarenes under thermal conditions is described. Improvements in catalyst design and performance were guided by precatalyst activation studies, where investigations into stoichiometric reactivities of iron borohydride (4- ^t Bu- ^iPrPDI)Fe(H₂BPin) and iron furyl (4- ^t Bu- ^iPrPDI)Fe(2-methylfuryl) complexes revealed facile C(sp²)-H activation and a slower and potentially turnover-limiting C(sp²)-B formation step. Formation of the flyover dimer, [(4- ^t Bu- ^iPrPDI)Fe]₂ was identified as a catalyst

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11563351 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature